In-game, their units are unit-for-unit more powerful than those of Nod and the Scrin. By the year 2047 GDI's forces have been restructured to allow for decentralized operations in multiple theatres of war, through the establishment of forward-operating bases in all types of terrain, and the deployment of proven, specialized and cost-effective ground and air forces supported by the most advanced network of orbital artillery satellites in history. The Brotherhood is notoriously adept at exploiting these weaknesses with a mixture of low-tech guerilla tactics and a combination of advanced Tiberium-based technologies. Global Defense Initiative troops utilize both superior armor and firepower, making them typically more powerful than their Nod counterparts - especially in open and direct engagements.However, GDI military doctrine has shown to be more cumbersome and lacking flexibility. Comparably, modern day armed forces lack the organisational, technological and numerical superiority of GDI armed forces.

GDI assets are able to deploy globally, quickly and with lethal force. GDI is capable of instantly deploying vast quantities of well-trained and well-equipped soldiers backed by powerful ground, air and naval assets. The Global Defense Initiative has a similar internal structure and administrative hierarchy to a modern day supranational body integrating the armies and resources of the richest and most powerful nations.

The three main factions of this series are the Global Defense Initiative, Brotherhood of Nod, and Scrin. The Tiberium series, which includes the original Command and Conquer game, is set in an alternate history. Tiberium series Main article: Command & Conquer: Tiberian series

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